I think I read on TVTropes that one of the ME games has the player character and an NPC having a snark war lampshading game mechanics, tropes, etc every time they're on a mission together.
"Why do they keep coming in WAVES? They'd pose much more of a threat all at once."
Stuff like that. Even if it "breaks the immersion", I always love it when at least one of the characters in a game is witty and meta-aware, bonus points if they only do it around certain others, who specifically acknowledge them as not being crazy.
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